Harris had held his current role since 2007, having joined the company 39 years ago.
During his time with the business he held a variety of roles, mostly as part of the firm’s pet care division.
In 2002 he was appointed ceo of Nestle Purina Pet Care Europe – receiving the added responsibility of Asia, Oceania and Africa three years later.
Nestlé ceo Paul Bulcke said Harris had made a strong contribution to the success of the company during almost four decades with the business.
“He successfully led the worldwide expansion of our water business and, in particular, our Perrier and S.Pellegrino international brands. John was also instrumental in further developing Nestlé Pure Life as the world's leading bottled water brand.”
Harris will be succeeded by Marco Settembri.